More of the Right Cells for Better Translational Medicine:
Bioprocessing Expansion of Cancer Stem Cells / Tumor Initiating Cells
Yonghyun (John) Kim, Ph.D.
Reichhold-Shumaker Assistant Professor
Chemical and Biological Engineering
The University of Alabama
Cancer stem cells (CSCs), which are also called tumor-initiating cells, are considered the stem cell-like pluripotent cancer cells that cause relapse in patients even after the most rigorous treatment. Pharmaceutical companies, however, typically use several decades-old cancer cell lines during their drug development because, among many reasons, CSCs are hard to acquire and are limited in number and expanding them without losing their stem characteristics is difficult. It is becoming increasingly recognized, however, drug development must be based on CSCs to develop better drugs that target the "real culprit" in tumors. Therefore, our work aims to bridge the oncologists with engineers by developing methods to acquire copious amounts of CSCs using bioengineering principles for the mass production of CSCs from primary patient tissues. In this seminar, I will be discussing our laboratory’s recent efforts in developing methods to improve the yield of CSCs using various media optimization and bioprocessing strategies. Through our work, we hope to provide foundation towards building CSC cell banks in the future.
Dr. John Kim is a Reichhold-Shumaker Assistant Professor of Chemical and Biological Engineering at the University of Alabama (UA). He received his B.S. in Chemical Engineering and B.A. in Biochemistry from Lafayette College (Easton, PA) in 2002, and his Ph.D. in Chemical and Biochemical Engineering from the University of Maryland Baltimore County (UMBC, Baltimore, MD) in 2008. He also received his post-doctoral training in oncology from Samsung Biomedical Research Institute (Seoul, South Korea) from 2008 to 2011, after which he joined UA in 2012 as an assistant professor. Dr. Kim was recently recognized as an outstanding undergraduate research mentor for having mentored three of his students to win the Goldwater Scholarships. He also serves as an Executive Committee member of the American Chemical Society Division of Biochemical Technology. He has over peer-reviewed 40 publications, and his research is currently funded by the National Science Foundation.
Thursday, January 18 at 2:00pm to 3:00pm
Earle Hall, 100
206 S. Palmetto Blvd., Clemson, SC 29634