Department of Physics and Astronomy
Clemson University, Kinard Lab of Physics, G01, Lecture Hall
Thursday, November 16, 4:00 pm
Department of Chemistry
University of Pennsylvania
Untangling tau: understanding function of a dysfunctional protein
Abstract: In contrast to globular proteins, intrinsically disordered proteins do not form stable, compact structures under physiological conditions. Rather, often their functions are derived from their properties as extended, flexible polymers. It has recently been recognized that intrinsically disordered proteins are involved in a range of functional roles in the cell, as well as being associated with a number of diverse diseases, including cancers, neurodegenerative disorders, and cardiac myopathies. We use single molecule fluorescence approaches to characterize both the ‘structures’ and dynamics of disordered proteins implicated in the progression of Parkinson's and Alzheimer's diseases. The focus of this talk is the interaction of the microtubule associated protein, tau, with a functional binding partner, soluble tubulin. We characterize alterations in tau structure upon binding to tubulin and investigate the underlying physico-chemical properties of tau relevant to its functional mechanism.
Bio: Elizabeth Rhoades got her B.S. degree in Physics from Duke University and pursued a Ph.D. in Biophysics from the University of Michigan. She worked on aggregation of islet amyloid polypeptide with Ari Gafni and Duncan Steel. She later took a Postdoctoral position at the Weizmann Institute in the lab of Gilad Haran in the Department of Chemical Physics working on single molecule approaches to protein folding. Subsequently, she was a Postdoc at Cornell University in the lab of Watt Webb in the Department of Applied Physics working on membrane interactions of alpha-synuclein. In 2006, she moved to UPenn and spent 9 years at the Department of Molecular Biophysics & Biochemistry as an assistant professor and in 2015, she moved to the Department of
Refreshments will be served after the presentation in the PandA Café.
Thursday, November 16 at 4:00pm to 5:00pm
Kinard Laboratory of Physics, G01 Kinard Lab
140 Delta Epsilon Ct., Clemson, SC 29634, USA