Department of Physics and Astronomy
Clemson University, Kinard Lab of Physics, G01, Lecture Hall
Thursday, September 20, 4:00 pm
Weiqiang Chen, Ph.D.
Department of Mechanical and Aerospace Engineering
New York University
Why Physics Matters for Cells: From Biology to Mechanics
Abstract: Many exciting topics exist at the interface between biology and mechanics. This seminar will discuss emerging topics in the field of cell biophysics and mechanobiology. At NYU, we are interested in probing cell mechanics using new micromechanical tools capable of applying controlled mechanical stress on cell while simultaneously reporting dynamic responses of subcellular cytoskeleton tension, energy and the corresponding morphological dynamics with a one-to-one spatial registration, so as to illustrate how the rapid, mechanosensitive dynamics of cell cytoskeleton tension and mechanical energies at a subcellular scale could collectively drive and regulate the mechanical allodynamic process of a single cell. I will also discuss how the distinct biomechanical attributes - endogenous intercellular traction-imbalance - in the cancer microenvironment contribute to the evolution of cancer stem cells and their tendencies toward tumorigenesis and metastasis, which may help to model cancer phenotype and develop personalized models for therapeutics. The new understanding of cell mechanics down to a subcellular scale can provide unprecedented biophysical insights into the origin and regulation of cell behaviors, dysregulations of which has been associated with pathophysiological conditions in developmental disorders, cardiovascular and inflammatory diseases, and cancer.
Bio: Dr. Weiqiang Chen is an Assistant Professor in the Department of Mechanical and Aerospace Engineering at New York University. He received his B.S. in Physics from Nanjing University in 2005 and M.S. degrees from Shanghai Jiao Tong University in 2008 and Purdue University in 2009, both in Electrical Engineering. He earned his Ph.D. degree in Mechanical Engineering from the University of Michigan in 2014. He is the receipt of American Heart Association Scientist Development Award, the NYU Whitehead Fellowship, the 2013 Baxter Young Investigator Award, the University of Michigan Richard F. & Eleanor A. Towner Prize for Outstanding PhD Research, and the ProQuest Distinguished Dissertation Award. Dr. Chen’s research interests focus on Lab-on-a-Chip, biomaterials, mechanobiology, stem cell biology, caner biology, immune engineering.
Refreshments will be served after the presentation in the P&A Café.
Thursday, September 20
Kinard Laboratory of Physics, G01 Kinard Lab
140 Delta Epsilon Ct., Clemson, SC 29634, USA