Department of Physics and Astronomy
Clemson University, Kinard Lab of Physics, G01, Lecture Hall
Thursday, March 15, 4:00 pm
School of Physics
Georgia Institute of Technology
Biophysics of DNA Strand Displacement
Abstract: DNA, which encodes the mystery of life, is one of the most important molecules in the universe. Unlike the static image of a double helix seen in textbooks, DNA exists in an extremely dynamic state. It can spontaneously stretch, bend, twist, and even unwind out of the double helix. In this aspect, DNA is nothing but a mechanical object that is governed by the laws of statistical physics. In this talk, I will give you a brief overview of DNA and illustrate how physical approaches can be used to observe and describe its subtle and complex motions. As an example, I will talk about a reaction called DNA strand displacement where a single DNA strand invades a double-stranded DNA molecule. I will explain how we measure first passage times for this one-step stochastic process and build a quantitative model of DNA strand displacement at the single nucleotide level.
Bio Sketch: Harold Kim majored in physics in KAIST, S. Korea and obtained his PhD from Stanford University under the supervision of Steven Chu. He did his postdoctoral research in the laboratory of Erin O’Shea at Harvard University. He received a Burroughs Wellcome Career Award at the Scientific Interfaces in 2007. He joined Georgia Tech as an Assistant Professor in 2010 and was promoted to Associate Professor in 2016. His laboratory studies the physical principles of genome organization using fluorescence and force microscopy. His research is funded by the National Institutes of Health and the National Science Foundation.
Refreshments will be served after the presentation in the P&A Café.
Thursday, March 15 at 4:00pm to 5:00pm
Kinard Laboratory of Physics, G01 Kinard Lab
140 Delta Epsilon Ct., Clemson, SC 29634, USA