Department of Physics and Astronomy
Meeting ID: 962 6907 1707
Thursday, March 4, 4:00 pm
Diving into chromatin in time and space
Queen’s University Medical School, Kingston, ON, Canada
Ontario Institute of Cancer Research, Toronto, ON, Canada
Abstract: In eukaryotes, DNA is packaged into chromatin and is dynamically accessed during transcription and replication processes with high spatiotemporal precision. This seemingly contradictory task of DNA packaging and dynamic access has been a topic of our recent studies. Nucleosomes represent the basic subunits of chromatin structure and comprise a histone octamer of four types of core histones, two copies each (H2A, H2B, H3, and H4) and ~147 bp of DNA wrapped around them. Intrinsically disordered histone tails flanking histone core domains play critical roles. Nucleosomes can bind linker histones H1 to regulate the degree of chromatin compaction. To gain insights into the intrinsic dynamics of nucleosomes, we apply all-atom molecular dynamics simulations and develop hybrid approaches by combining experimental data with molecular modelling approaches. In my talk, I will focus on our most recent projects pertaining to the roles of dynamic histones tails and histone H1 in regulating the chromatin compaction and binding of partners to nucleosomes.
Bio: Anna Panchenko received her B.S. (1989) and PhD (1993) from the Biophysics Department of Moscow State University in Russia, where she studied protein dynamics by Mossbauer spectroscopy. She came to the USA as an NSF visiting fellow and subsequently worked as a post-doctoral fellow in the School of Chemical Science of the University of Illinois at Urbana- Champaign. While at UIUC, she studied the kinetics of ligand binding to myoglobin and protein folding. In September 1997 Anna joined NCBI of the National Institutes of Health, USA, as an IRTA Research Fellow, later as a Staff Scientist and then as a Lead Scientist. Her team worked on the development of computational algorithms for the analysis of protein sequence and structure, protein-protein interactions, identifying cancer driver events and chromatin dynamics. In July 2019 she was recruited to the Queen's University School of Medicine as a professor and Canada Research Chair Tier 1. She also holds a Senior Investigator position at the Ontario Institute of Cancer Research in Toronto. Anna is an author of one book on protein-protein interactions and more than 100 publications in peer-reviewed journals. Her expertise has been recognized by her international academic peers, she was elected as an organizer of several international conferences including the world-renowned Keystone Symposium and Gordon Research Conferences, and currently an editor of the two leading scientific journals, Journal of Molecular Biology and PloS Computational Biology.
Meeting ID: 962 6907 1707
Thursday, March 4, 2021 at 4:00pm to 5:00pmVirtual Event